Quantifying Co-Oligomer Formation by α-Synuclein
نویسندگان
چکیده
منابع مشابه
Computational Study on Oligomer Formation of Fibril-forming Peptide of α-Synuclein
We have studied the oligomerization of a fibril-forming segment of α-Synulcein using a replica exchange molecular dynamics (REMD) simulation. The simulation was performed with trimers and tetramers of a 12 amino acid residue stretch (residues 71-82) of α-Synulcein. From extensive REMD simulations, we observed the spontaneous formation of both trimer and tetramer, demonstrating the self-aggregat...
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In Parkinson's disease (PD) and other α-synucleinopathies, prefibrillar α-synuclein (αS) oligomer is implicated in the pathogenesis. However, toxic αS oligomers observed using in vitro systems are not generally seen to be associated with α-synucleinopathy in vivo. Thus, the pathologic significance of αS oligomers to αS neurotoxicity is unknown. Herein, we show that, αS that accumulate within en...
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Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide and characterized by the loss of dopaminergic neurons in the patients' midbrains. Both the presence of the protein α-synuclein in intracellular protein aggregates in surviving neurons and the genetic linking of the α-synuclein encoding gene point towards a major role of α-synuclein in PD etiology. The exa...
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ژورنال
عنوان ژورنال: ACS Nano
سال: 2018
ISSN: 1936-0851,1936-086X
DOI: 10.1021/acsnano.8b03575